منابع مشابه
DNA replication licensing and human cell proliferation.
The convergence point of growth regulatory pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly of pre-replicative complexes resulting in chromatin being "licensed" for DNA replication in the subsequent S phase. We have analysed regulation of the pre-replicative complex proteins ORC, Cdc6, and MCM in cycling and non-proliferating qu...
متن کاملDNA damage, DNA repair, cell proliferation, and DNA replication: how do gene mutations result?
M son enjoys visiting my lab on weekends because the university internet connection is much faster than our home modem connection. He also likes to read DNA sequences to find that single base change that often spells the cause of human genetic disease. And, when he finds a change, he asks me how it occurred. We discuss DNA damage, repair, and replication, but I can never exactly answer that ‘‘h...
متن کاملDNA replication licensing affects cell proliferation or endoreplication in a cell type-specific manner.
In eukaryotic cells, the function of DNA replication licensing components (Cdc6 and Cdt1, among others) is crucial for cell proliferation and genome stability. However, little is known about their role in whole organisms and whether licensing control interfaces with differentiation and developmental programs. Here, we study Arabidopsis thaliana CDT1, its regulation, and the consequences of over...
متن کاملSine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer.
Malignant proliferation is the fundamental trait of tumor cells. The initiation of DNA replication represents a key process for cell proliferation, and has a marked impact on tumorigenesis and progression. Here we report that Sine oculis homeobox homolog 1 (SIX1) functions as a master regulator in DNA replication of cervical cancer cells. The expression of SIX1 was induced by the E7 oncoprotein...
متن کاملPolycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour suppressor locus Ink4a/Arf, whose products positively regulate pRb and p53 functions. Enhanced PcG activity is a frequent feature of human tumours, and PcG inhibition has been proposed as a strategy for cancer treatment. However, the rec...
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ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1992
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.30.495